FlexServ: an integrated tool for the analysis of protein flexibility.
|Title||FlexServ: an integrated tool for the analysis of protein flexibility.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Camps, Jordi, Carrillo Oliver, Emperador Agustí, Orellana Laura, Hospital Adam, Rueda Manuel, Cicin-Sain Damjan, D’Abramo Marco, Gelpí Josep-Lluis, and Orozco Modesto|
|Date Published||2009 Jul 1|
|Keywords||Computational Biology, Databases, Internet, Protein, Protein Conformation, Proteins, Sequence Analysis, Software|
SUMMARY: FlexServ is a web-based tool for the analysis of protein flexibility. The server incorporates powerful protocols for the coarse-grained determination of protein dynamics using different versions of Normal Mode Analysis (NMA), Brownian dynamics (BD) and Discrete Dynamics (DMD). It can also analyze user provided trajectories. The server allows a complete analysis of flexibility using a large variety of metrics, including basic geometrical analysis, B-factors, essential dynamics, stiffness analysis, collectivity measures, Lindemann’s indexes, residue correlation, chain-correlations, dynamic domain determination, hinge point detections, etc. Data is presented through a web interface as plain text, 2D and 3D graphics.