FlexServ: an integrated tool for the analysis of protein flexibility.
| Title | FlexServ: an integrated tool for the analysis of protein flexibility. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Camps, Jordi, Carrillo Oliver, Emperador Agustí, Orellana Laura, Hospital Adam, Rueda Manuel, Cicin-Sain Damjan, D’Abramo Marco, Gelpí Josep-Lluis, and Orozco Modesto |
| Journal | Bioinformatics |
| Volume | 25 |
| Pagination | 1709-10 |
| Date Published | 2009 Jul 1 |
| ISSN | 1367-4811 |
| Keywords | Computational Biology, Databases, Internet, Protein, Protein Conformation, Proteins, Sequence Analysis, Software |
| Abstract | SUMMARY: FlexServ is a web-based tool for the analysis of protein flexibility. The server incorporates powerful protocols for the coarse-grained determination of protein dynamics using different versions of Normal Mode Analysis (NMA), Brownian dynamics (BD) and Discrete Dynamics (DMD). It can also analyze user provided trajectories. The server allows a complete analysis of flexibility using a large variety of metrics, including basic geometrical analysis, B-factors, essential dynamics, stiffness analysis, collectivity measures, Lindemann’s indexes, residue correlation, chain-correlations, dynamic domain determination, hinge point detections, etc. Data is presented through a web interface as plain text, 2D and 3D graphics. AVAILABILITY: http://mmb.pcb.ub.es/FlexServ; http://www.inab.org |
| DOI | 10.1093/bioinformatics/btp304 |