8-Amino guanine accelerates tetramolecular G-quadruplex formation.

Title8-Amino guanine accelerates tetramolecular G-quadruplex formation.
Publication TypeJournal Article
Year of Publication2008
AuthorsGros, Julien, Aviñó Anna, de la Osa Jaime Lopez, González Carlos, Lacroix Laurent, Pérez Alberto, Orozco Modesto, Eritja Ramon, and Mergny Jean-Louis
JournalChem Commun (Camb)
Pagination2926-8
Date Published2008 Jul 7
ISSN1359-7345
KeywordsBase Sequence, Circular Dichroism, G-Quadruplexes, Guanine, Molecular Structure, Nucleic Acid Denaturation, Temperature
Abstract

We demonstrate here that 8-amino guanine () strongly accelerates quadruplex formation, which makes this nucleobase the most attractive replacement for guanine in the context of tetramolecular parallel quadruplexes.

DOI10.1039/b801221k