Relative flexibility of DNA and RNA: a molecular dynamics study.

TitleRelative flexibility of DNA and RNA: a molecular dynamics study.
Publication TypeJournal Article
Year of Publication2004
AuthorsNoy, Agnes, Pérez Alberto, Lankaš Filip, F Luque Javier, and Orozco Modesto
JournalJ Mol Biol
Date Published2004 Oct 22
KeywordsComputer Simulation, DNA, Models, Molecular, Nucleic Acid Conformation, Pliability, RNA, Thermodynamics

State of the art molecular dynamics simulations are used to study the structure, dynamics, molecular interaction properties and flexibility of DNA and RNA duplexes in aqueous solution. Special attention is paid to the deformability of both types of structures, revisiting concepts on the relative flexibility of DNA and RNA duplexes. Our simulations strongly suggest that the concepts of flexibility, rigidity and deformability are much more complex than usually believed, and that it is not always true that DNA is more flexible than RNA.