Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells

TitleEfficient siRNA-peptide conjugation for specific targeted delivery into tumor cells
Publication TypeJournal Article
Year of Publication2017
AuthorsGandioso, Albert, Massaguer Anna, Villegas Núria, Salvans Cándida, Sanchez Dani, Brun-Heath Isabelle, Marchan Vicente, Orozco Modesto, and Terrazas Montserrat
JournalChemical Communications
Volume53
Issue19
Pagination2870 - 2873
Date Published03/2017
ISBN Number1359-7345
Abstract

Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides still remains a challenge. Here we describe a straightforward method for the click functionalization of siRNAs with peptides of different sizes and complexities. Among them, a promising peptide carrier for the selective siRNA delivery into HER2+ breast cancer cell lines has been reported.

URLhttp://dx.doi.org/10.1039/C6CC10287E
Short TitleChem. Commun.
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