Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells
| Title | Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Gandioso, Albert, Massaguer Anna, Villegas Núria, Salvans Cándida, Sanchez Dani, Brun-Heath Isabelle, Marchan Vicente, Orozco Modesto, and Terrazas Montserrat |
| Journal | Chemical Communications |
| Volume | 53 |
| Issue | 19 |
| Pagination | 2870 - 2873 |
| Date Published | 03/2017 |
| ISBN Number | 1359-7345 |
| Abstract | Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides still remains a challenge. Here we describe a straightforward method for the click functionalization of siRNAs with peptides of different sizes and complexities. Among them, a promising peptide carrier for the selective siRNA delivery into HER2+ breast cancer cell lines has been reported. |
| URL | http://dx.doi.org/10.1039/C6CC10287E |
| Short Title | Chem. Commun. |
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