Multiscale simulation of DNA

TitleMultiscale simulation of DNA
Publication TypeJournal Article
Year of Publication2016
AuthorsDans, Pablo D., Walther Jurgen, Gómez Hansel, and Orozco Modesto
JournalCurrent Opinions in Structural Biology - Theory and simulation • Macromolecular machines 2016
Pagination29 - 45
Date Published02/2016
ISBN Number0959-440X

DNA is not only among the most important molecules in life, but a meeting point for biology, physics and chemistry, being studied by numerous techniques. Theoretical methods can help in gaining a detailed understanding of DNA structure and function, but their practical use is hampered by the multiscale nature of this molecule. In this regard, the study of DNA covers a broad range of different topics, from sub-Angstrom details of the electronic distributions of nucleobases, to the mechanical properties of millimeter-long chromatin fibers. Some of the biological processes involving DNA occur in femtoseconds, while others require years. In this review, we describe the most recent theoretical methods that have been considered to study DNA, from the electron to the chromosome, enriching our knowledge on this fascinating molecule.

Short TitleCurrent Opinion in Structural Biology