Inntags: new tools for innocuous protein tagging
A study conducted in collaboration with the CSIC, BSC and UB provides a new approach to follow cellular proteins more closely.
Last most-relevant publications
- Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes
- Prevalent Sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH Journal of the American Chemical Society
- Structural basis of a histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistance Proc. Natl. Acad. Sci, USA
Researchers measure a property of DNA for the first time
The electric polarizability of DNA is a fundamental property that directly influences its biological functions.
ParmBSC1 force-field
ParmBSC1 forcefield, a refined force-field for the atomistic simulation of DNA.
When a denaturant stabilizes DNA
Combination of two strong denaturants of DNA leads to stabilization of the structure
The transmission of information via proteins could revolutionize drug discovery
A study by the scientists Xavier Salvatella and Modesto Orozco at IRB Barcelona reveals the existence of information highways that connect and correlate distant sites within a single protein.
Published in Nature Communications, the article furthers a key theoretical field for drug discovery, as it would allow the discovery of many more drug binding sites in proteins of biomedical interest.