Effects of local electric fields on the redox free energy of single stranded DNA.

TitleEffects of local electric fields on the redox free energy of single stranded DNA.
Publication TypeJournal Article
Year of Publication2011
AuthorsD’Abramo, Marco, Orozco Modesto, and Amadei Andrea
JournalChem Commun (Camb)
Volume47
Pagination2646-8
Date Published2011 Mar 7
ISSN1364-548X
KeywordsDNA, Electrochemical Techniques, Models, Oxidation-Reduction, Quantum Theory, Single-Stranded, Theoretical, Thermodynamics
Abstract

Influence of external electric field as well as base substitution effects on the reduction/oxidation free energies of single stranded DNA suggest that base sequencing via measuring redox properties might be feasible under the conditions that (i) a difference of \~{} 230 kJ mol(-1) in the oxidation potentials is enough to discriminate between nucleobases conductance signals and (ii) the strand is long enough to reduce end effects.
DOI10.1039/c0cc04352d