FlexServ: an integrated tool for the analysis of protein flexibility.

TitleFlexServ: an integrated tool for the analysis of protein flexibility.
Publication TypeJournal Article
Year of Publication2009
AuthorsCamps, Jordi, Carrillo Oliver, Emperador Agustí, Orellana Laura, Hospital Adam, Rueda Manuel, Cicin-Sain Damjan, D’Abramo Marco, Gelpí Josep-Lluis, and Orozco Modesto
Date Published2009 Jul 1
KeywordsComputational Biology, Databases, Internet, Protein, Protein Conformation, Proteins, Sequence Analysis, Software

SUMMARY: FlexServ is a web-based tool for the analysis of protein flexibility. The server incorporates powerful protocols for the coarse-grained determination of protein dynamics using different versions of Normal Mode Analysis (NMA), Brownian dynamics (BD) and Discrete Dynamics (DMD). It can also analyze user provided trajectories. The server allows a complete analysis of flexibility using a large variety of metrics, including basic geometrical analysis, B-factors, essential dynamics, stiffness analysis, collectivity measures, Lindemann’s indexes, residue correlation, chain-correlations, dynamic domain determination, hinge point detections, etc. Data is presented through a web interface as plain text, 2D and 3D graphics.

AVAILABILITY: https://mmb.pcb.ub.es/FlexServ; https://www.inab.org