Determining promoter location based on DNA structure first-principles calculations.

TitleDetermining promoter location based on DNA structure first-principles calculations.
Publication TypeJournal Article
Year of Publication2007
AuthorsJ Goñi, Ramon, Pérez Alberto, Torrents David, and Orozco Modesto
JournalGenome Biol
Volume8
PaginationR263
Date Published2007
ISSN1474-760X
KeywordsAlgorithms, DNA, Gene Expression, Genetic, Humans, Oligonucleotides, Promoter Regions, Software
Abstract

A new method for the prediction of promoter regions based on atomic molecular dynamics simulations of small oligonucleotides has been developed. The method works independently of gene structure conservation and orthology and of the presence of detectable sequence features. Results obtained with our method confirm the existence of a hidden physical code that modulates genome expression.

DOI10.1186/gb-2007-8-12-r263
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