PMUT: a web-based tool for the annotation of pathological mutations on proteins.
|Title||PMUT: a web-based tool for the annotation of pathological mutations on proteins.|
|Publication Type||Journal Article|
|Year of Publication||2005|
|Authors||Ferrer-Costa, Carles, Gelpí Josep-Lluis, Zamakola Leire, Párraga Iván, de la Cruz Xavier, and Orozco Modesto|
|Date Published||2005 Jul 15|
|Keywords||Amino Acid Substitution, Chemical, Computer Simulation, Internet, Models, Molecular, Mutagenesis, Neural Networks (Computer), Protein, Proteins, Sequence Alignment, Sequence Analysis, Site-Directed, Software, User-Computer Interface|
PMUT allows the fast and accurate prediction (approximately 80% success rate in humans) of the pathological character of single point amino acidic mutations based on the use of neural networks. The program also allows the fast scanning of mutational hot spots, which are obtained by three procedures: (1) alanine scanning, (2) massive mutation and (3) genetically accessible mutations. A graphical interface for Protein Data Bank (PDB) structures, when available, and a database containing hot spot profiles for all non-redundant PDB structures are also accessible from the PMUT server.