New Nucleic Acids Force-Field

We have developed the parmbsc0 force field, a refinement of the AMBER parm99 force field, where emphasis has been made on the correct representation of the a/g concerted rotation in nucleic acids (NAs). The modified force field corrects overpopulations of the a/g 1⁄4 (g1,t) backbone that were seen in long (more than 10 ns) simulations with previous AMBER parameter sets (parm94-99). The force-field is considered the “gold standard” in the field. PARMBSC1, a new refinement with improved performance for normal and inusual nucleic acids will appear in 2014. [1]