PMut: Pathological Mutations
PMUT allows the fast and accurate prediction (approximately 80% success rate in humans) of the pathological character of single point amino acidic mutations based on the use of neural networks. The program also allows the fast scanning of mutational hot spots, which are obtained by three procedures: (1) alanine scanning, (2) massive mutation and (3) genetically accessible mutations. A graphical interface for Protein Data Bank (PDB) structures, when available, and a database containing hot spot profiles for all non-redundant PDB structures are also accessible from the PMUT server.
Victor López-Ferrando, Andrea Gazzo, Xavier de la Cruz, Modesto Orozco, Josep Lluís Gelpí
PMut: a web-based tool for the annotation of pathological variants on proteins, 2017 update
Nucleic Acids Research. (2017) 45(W1), W222-W228.
Carles Ferrer Costa, Josep Lluís Gelpí, Leire Zamacola, Iván Párraga, Xavier de la Cruz, Modesto Orozco.
PMut: a web-based tool for the annotation of pathological mutations on proteins.
Bioinformatics. (2005) 21(14), 3176-3178.