Nucleosome Dynamics: a new tool for the dynamic analysis of nucleosome positioning

TitleNucleosome Dynamics: a new tool for the dynamic analysis of nucleosome positioning
Publication TypeJournal Article
Year of Publication2019
AuthorsBuitrago, Diana, Codó Laia, Illa Ricard, de Jorge Pau, Battistini Federica, Flores Oscar, Bayarri Genis, Royo Romina, Del Pino Marc, Heath Simon, Hospital Adam, Gelpí Josep Lluis, Heath Isabelle Brun, and Orozco Modesto
JournalNucleic Acids Research
Date Published08/2019
ISBN Number0305-1048

We present Nucleosome Dynamics, a suite of programs integrated into a virtual research environment and created to define nucleosome architecture and dynamics from noisy experimental data. The package allows both the definition of nucleosome architectures and the detection of changes in nucleosomal organization due to changes in cellular conditions. Results are displayed in the context of genomic information thanks to different visualizers and browsers, allowing the user a holistic, multidimensional view of the genome/transcriptome. The package shows good performance for both locating equilibrium nucleosome architecture and nucleosome dynamics and provides abundant useful information in several test cases, where experimental data on nucleosome position (and for some cases expression level) have been collected for cells under different external conditions (cell cycle phase, yeast metabolic cycle progression, changes in nutrients or difference in MNase digestion level). Nucleosome Dynamics is a free software and is provided under several distribution models.

Short TitleNucleic Acids Research