Correlated motions in DNA: beyond base-pair step models of DNA flexibility

TitleCorrelated motions in DNA: beyond base-pair step models of DNA flexibility
Publication TypeJournal Article
Year of Publication2023
AuthorsLópez-Güell, Kim, Battistini Federica, and Orozco Modesto
JournalNucleic Acids Research
Volume51
Issue6
Pagination2633 - 2640
Date Published06/2023
ISBN Number0305-1048
Abstract

Traditional mesoscopic models of DNA flexibility use a reductionist-local approach, which assumes that the flexibility of DNA can be expressed as local harmonic movements (at the base-pair step level) in the helical space, ignoring multimodality and correlations in DNA movements, which have in reality a large impact in modulating DNA movements. We present a new multimodal-harmonic correlated model, which takes both contributions into account, providing, with a small computational cost, results of an unprecedented local and global quality. The accuracy of this method and its computational efficiency make it an alternative to explore the dynamics of long segments of DNA, approaching the chromatin range.

URLhttps://doi.org/10.1093/nar/gkad136
Short TitleNucleic Acids Research
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