Correlated motions are a fundamental property of B-sheets
|Correlated motions are a fundamental property of B-sheets
|Year of Publication
|R. Fenwick, Bryn, Orellana Laura, Esteban-Martí-n Santi, Orozco Modesto, and Salvatella Xavier
Correlated motions in proteins can mediate fundamental biochemical processes such as signal transduction and allostery. The mechanisms that underlie these processes remain largely unknown due mainly to limitations in their direct detection. Here, based on a detailed analysis of protein structures deposited in the protein data bank, as well as on state-of-the art molecular simulations, we provide general evidence for the transfer of structural information by correlated backbone motions, mediated by hydrogen bonds, across B-sheets. We also show that the observed local and long-range correlated motions are mediated by the collective motions of B-sheets and investigate their role in large-scale conformational changes. Correlated motions represent a fundamental property of B-sheets that contributes to protein function.