Inntags: new tools for innocuous protein tagging
A study conducted in collaboration with the CSIC, BSC and UB provides a new approach to follow cellular proteins more closely.
Last most-relevant publications
- Molecular stripping underpins derepression of a toxin–antitoxin system Nat Struct Mol Biol
- Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α Nature Communications
- Nucleic acids in modern molecular therapies: A realm of opportunities for strategic drug design Current Opinion in Structural Biology
- Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair Nature Communications
Researchers measure a property of DNA for the first time
The electric polarizability of DNA is a fundamental property that directly influences its biological functions.
ParmBSC1 force-field
ParmBSC1 forcefield, a refined force-field for the atomistic simulation of DNA.
When a denaturant stabilizes DNA
Combination of two strong denaturants of DNA leads to stabilization of the structure
The transmission of information via proteins could revolutionize drug discovery
A study by the scientists Xavier Salvatella and Modesto Orozco at IRB Barcelona reveals the existence of information highways that connect and correlate distant sites within a single protein.
Published in Nature Communications, the article furthers a key theoretical field for drug discovery, as it would allow the discovery of many more drug binding sites in proteins of biomedical interest.